Item name:
Imitrex (GlaxoSmithKline)
Generic Name:
sumatriptan
Brand names:
Imitrex
Item info:
Sumatriptan is a headache medicine. It is believed to work by narrowing the blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Sumatriptan injection is used to treat migraine headaches and cluster headaches. Sumatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
Drug class:
a selective 5-hydroxytryptamine 1 receptor subtype agonist.
Interactions:
Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because there is a theoretical basis that these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and sumatriptan within 24 hours of each other should be avoided.
MAO-A inhibitors reduce sumatriptan clearance, significantly increasing systemic exposure. Therefore, the use of IMITREX Tablets in patients receiving MAO-A inhibitors is contraindicated.
Side effects:
Some patients experience pain or tightness in the chest or throat when using IMITREX Tablets. If this happens to you, then discuss it with your doctor before using any more IMITREX Tablets. If the chest pain is severe or does not go away, call your doctor immediately. If you have sudden and/or severe abdominal pain following IMITREX Tablets, call your doctor immediately.
Shortness of breath; wheeziness; heart throbbing; swelling of eyelids, face, or lips; or a skin rash, skin lumps, or hives happens rarely. If it happens to you, then tell your doctor immediately.
Do not take any more IMITREX Tablets unless your doctor tells you to do so. Some people may have feelings of tingling, heat, flushing (redness of face lasting a short time), heaviness or pressure after treatment with IMITREX Tablets. A few people may feel drowsy, dizzy, tired, or sick. Tell your doctor of these symptoms at your next visit. If you feel unwell in any other way or have any symptoms that you do not understand, you should contact your doctor immediately.
Prescription needed / OTC:
Prescription only
Dosage:
Use this medication exactly as it was prescribed for you. Do not use the medication in larger or smaller amounts, or use it for longer than recommended by your doctor.
For adults, the usual dose is a single tablet taken whole with water or other fluids.
Do not split tablets.
A second tablet may be taken if your symptoms of migraine come back or if you have a partial response to the initial dose, but not sooner than 2 hours following the first tablet. For a given attack, if you have no response to the first tablet, do not take a second tablet without first consulting with your doctor.
Do not take more than a total of 200 mg of IMITREX Tablets in any 24-hour period. The safety of treat-ing an average of more than 4 headaches in a 30-day period has not been established.
Contraindications:
IMITREX Tablets should not be given to patients with history, symptoms, or signs of ischemic cardiac, cerebrovascular, or peripheral vascular syndromes.
In addition, patients with other significant underlying cardiovascular diseases should not receive IMITREX Tablets. Ischemic cardiac syndromes include, but are not limited to, angina pectoris of any type (e.g., stable angina of effort and vasospastic forms of angina such as the Prinzmetal variant), all forms of myocardial infarction, and silent myocardial ischemia. Cerebrovascular syndromes include, but are not limited to, strokes of any type as well as transient ischemic attacks. Peripheral vascular disease includes, but is not limited to, ischemic bowel disease.
Because IMITREX Tablets may increase blood pressure, they should not be given to patients with uncontrolled hypertension. Concurrent administration of MAO-A inhibitors or use within 2 weeks of discontinuation of MAO-A inhibitor therapy is contraindicated IMITREX Tablets should not be administered to patients with hemiplegic or basilar migraine.
IMITREX Tablets and any ergotamine-containing or ergot-type medication (like dihydroergotamine or methysergide) should not be used within 24 hours of each other, nor should IMITREX and another 5-HT 1 agonist. IMITREX Tablets are contraindicated in patients with hypersensitivity to sumatriptan or any of their components. IMITREX Tablets are contraindicated in patients with severe hepatic impairment.
Storage:
Store this medicine at room temperature away from moisture, heat, and light.